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ANESTHETIZED MODELS

Our specialized anesthetized models are some of the most sensitive assays to detect cardiovascular effects of lead compounds, conduct primary evaluations and explore the potential of backups.

With anesthetized subjects, the CorDynamics team performs comprehensive cardiovascular examinations.

Advanced hemodynamics
Heart rate
Systemic blood pressures
Pulmonary artery pressures
Left ventricular pressures and derivatives
Cardiac output
Blood flow
PK/PD relationships
Electrocardiograms
Electrophysiological testing

Our facilities feature dedicated surgical suites using multiple species, modes, anesthetics, dose routes and regimens. All our anesthetized models meet or exceed the requirements for global regulatory submission but can be leveraged for discovery cardiovascular studies as well. The data acquisition platforms we use are fully validated, including Notocord, Data Sciences International and EMKA.

The CorDynamics quality assurance unit has extensive GLP and OECD experience with cardiovascular safety pharmacology studies and maintains the highest degree of study integrity.