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ATRIAL FIBRILLATION

CorDynamics has extensive experience working with project teams throughout their drug discovery steps—including a number of models for investigating atrial fibrillation.

    Isolated Langendorff Heart

  • Poised for early discovery screening studies, including electrophysiology data.
  • Compound sparing.
  • Rapid turnaround with flexible design.

    Anesthetized dog

  • Acute induction via vagal pacing with epinephrine.
  • Complete cardiac electrophysiology available (atrial, AV nodal, His bundle, ventricular).

    Telemetry

  • Chronic rapid atrial pacing in canines—electrical and structural remodeling consistent with the clinical scenario.
  • Inducible AF with complete electrophysiology measurements.
  • Concurrent ECG and hemodynamics.
  • Multiple compounds in the same animal (consistent with 3Rs).
  • Provide a detailed interrogation alongside tolerability and PK/PD information.

Our preclinical investigations have helped to enable clinical trials while also satisfying rigorous scientific criteria.