CorDynamics has extensive experience working with project teams throughout their drug discovery steps—including a number of models for investigating atrial fibrillation.
- Acute induction via vagal pacing with epinephrine.
- Complete cardiac electrophysiology available (atrial, AV nodal, His bundle, ventricular).
- Chronic rapid atrial pacing in canines—electrical and structural remodeling consistent with the clinical scenario.
- Inducible AF with complete electrophysiology measurements.
- Concurrent ECG and hemodynamics.
- Multiple compounds in the same animal (consistent with 3Rs).
- Provide a detailed interrogation alongside tolerability and PK/PD information.
Our preclinical investigations have helped to enable clinical trials while also satisfying rigorous scientific criteria.