Drug Discovery: Models for Investigating Thrombosis
When clients approach us with our thoughts on investigating potential anti-thrombotic treatments we typically start by suggesting they consider our well-characterized mouse model.
The model, where we produce a carotid arterial thrombus using a process that can be interrupted by efficacious test articles, provides a deeper understanding of the biological pathways associated with thrombosis.
Briefly, we dose mice with either vehicle or active test article prior to administration of FeCl3 to the external surface of the carotid artery. Following this exposure to FeCl3, thrombotic occlusion of the carotid artery occurs in a matter of minutes in the untreated animal. Test article efficacy can be quantitated as alterations in coronary artery blood flow along with time to occlusion.