Producing PAH Results: Elaborating on Collaborating
Drug development researchers have been putting a lot of emphasis on collaborating in the effort to produce safe and effective drugs as quickly as possible. This is especially true in the area of rare disease research.
The CorDynamics team collaborates day in and day out—with each other, with colleagues, with our clients and their project teams. But collaborating is kind of like parenting, you think and hope you are doing it well but there isn’t a definitive gauge to tell you if you are making progress.
Well lo and behold, a tangible affirmation of collaboration was recently celebrated in our lab. CorDynamics Senior Scientist Dr. Liomar Neves, with our colleagues at Corridor Pharmaceuticals, demonstrated the novel serotonin receptor antagonist C-122 prevents monocrotaline induced pulmonary arterial hypertension (PAH) in rats in a paper published in the European Journal of Pharmacology.
PAH—an orphan disease, with unmet medical treatment—is characterized by increased blood pressure in the arteries of lungs, causing dizziness, shortness of breath and can lead to heart failure. Current therapies for pulmonary artery hypertension (PAH) improve longevity and performance of daily activities in the lives of PAH patients, but do not notably affect the disease processes that lead to morbidity and mortality. Since serotonin has a definitive role in the development of PAH, the authors hypothesized that interfering with serotonin function may reduce the vascular remodeling and hemodynamic changes that occur in this preclinical model.
With the industry continuing to embrace a collaborative environment, I look forward to more research results that will ultimately provide more treatment options for patients in the future. As far as my kids and my parenting skills go, I guess I’ll have to assume no coal in their stockings means I’m doing something right and continue to believe.
‘Til we collaborate again….
Theresa Gralinski, CorDynamics Marketing Director
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