Over the course of my career, I’ve been asked the following questions many times:
1. What is QT Interval Prolongation?
2. Why does it matter?
QT Interval Prolongation is an increase in the time the heart normally takes to ‘reset’ itself electrically.
QT Interval Prolongation is a critical matter in drug development for several reasons.
• Drugs that increase QT interval can make the heart vulnerable to life-threatening arrhythmias.
• It is one of the leading causes for drug withdrawal over the last 20 years.
• Screening new compounds for QT interval prolongation early in development can save millions of dollars.
Is there more you’d like to know about QT Interval prolongation? The long story perhaps?
If so, get in touch. I’m happy to elaborate further.
Filed under: Anesthetized Models, Cardiac Ion Channels, Drug Safety Services, Langendorff Heart, Telemetry | No Comments