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Electrophysiology

We have conducted these interrogations for a wide variety of client needs—from drug discovery to addressing clinical holds. Proarrythmia studies can also be included as part of a safety pharmacology assessment.

Our experienced team is well versed in the sophisticated techniques and instrumentation needed to delve deeper into top-line results to accurately determine, in detail, whether or not a compound is exhibiting any cardiac effects.

atrial conduction, refractoriness, arrhythmogenesis
atrioventricular nodal conduction, refractoriness
His bundle electrocardiography
ventricular conduction, refractoriness, arrhythmogenesis
monophasic action potential duration
programmed electrical stimulation protocols
pharmacokinetic-pharmacodynamic relationships

At CorDynamics we can also go further, actively creating a vulnerable electrical substrate to see how the compound affects cardiac electrophysiology in different experimental scenarios. This is particularly useful in selected safety assessments, and critical in discovery electropharmacology studies.