We have conducted these interrogations for a wide variety of client needs—from drug discovery to addressing clinical holds. Proarrythmia studies can also be included as part of a safety pharmacology assessment.
Our experienced team is well versed in the sophisticated techniques and instrumentation needed to delve deeper into top-line results to accurately determine, in detail, whether or not a compound is exhibiting any cardiac effects.
atrial conduction, refractoriness, arrhythmogenesis
atrioventricular nodal conduction, refractoriness
His bundle electrocardiography
ventricular conduction, refractoriness, arrhythmogenesis
monophasic action potential duration
programmed electrical stimulation protocols
At CorDynamics we can also go further, actively creating a vulnerable electrical substrate to see how the compound affects cardiac electrophysiology in different experimental scenarios. This is particularly useful in selected safety assessments, and critical in discovery electropharmacology studies.