CorDynamics offers a variety of discovery models designed to investigate heart failure. These customized assessments leverage physiologically relevant paradigms with expert design and follow through to enable key lead optimization in drug discovery.
Our experience with these complicated heart failure models enable us to interrogate the effects of new compounds in multiple modes.
Isoproterenol induced diastolic dysfunction
Transverse aortic constriction pressure overload
Post myocardial infarction remodeling
Dahl salt sensitive chronic hypertension
Tachypacing induced ventricular dysfunction
Advanced conscious instrumented models
Chronic cardiac output and left ventricular function