At CorDynamics, we leverage our extensive expertise and sophisticated data acquisition platforms to offer advanced hemodynamic measurements.
We can incorporate advanced hemodynamics into all our models—including the isolated Langendorff heart model, anesthetized subjects, and telemetry studies. Our skilled technicians have specialized surgical expertise and regularly perform these procedures in our laboratory. This know-how combined with the use of state-of-art data acquisition systems ensures quality throughout the study duration.
Our expertise and capabilities in both hemodynamic and electrophysiologic assessments allow for a comprehensive interrogation of a test article effect on cardiovascular function and an ability to provide a deeper assessment of potential cardiovascular liabilities.
Hemodynamic parameters available for interrogation:
- Left and right ventricular pressures (derivatives)
- Blood flow (arterial, venous, skin)
- Pulmonary arterial hemodynamics
- Cardiac output
- Pressure-volume loop analysis
By including advanced hemodynamic parameters, CorDynamics can uncover or exclude cardiovascular safety issues with lead compounds or backups. In addition, we use these techniques to address preclinical drug discovery heart failure, pulmonary arterial hypertension, thrombosis and ischemia/reperfusion questions.