NASH/Portal Hypertension

CorDynamics is currently validating and developing models of NASH in both mice and rats. We are studying a high fat diet supplemented with cholesterol and combined with bile duct ligation surgery to induce NASH over time. We are also validating a choline deficient high fat diet in mice. While we expect to induce NASH in the liver of these rodents, we are also very interested in how these diets and liver phenotypes affect cardiovascular physiology and hemodynamics overall.